Have plenty of space on your phone or camera for all of the photo ops available. Also, come hungry for all the treats on site for purchase in the café.
Wall Drug is a large place that attracts many visitors coming and going all the time, so keep your little ones close. If you go in the summer, there is a small splash pad in the play area. Wall Drug is also out in the middle of nowhere, so make sure you leave with plenty of fuel, water and snacks for the next leg of the journey.
Wall Drug has long hours and is open daily, however you should always check its website in case of closures.
Warmer weather is best because you can experience the outdoor areas of Wall Drug as well as indoors. South Dakota is notorious for bitterly cold and snowy winters. If you travel through during the cold season, be prepared for poor conditions. Wall Drug is also along the route to/from Sturgis, South Dakota. If you're traveling during the Sturgis Motorcycle Rally, be aware of the many motorcycles.